Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 1136-1141.DOI: 10.6023/cjoc201811026 Previous Articles     Next Articles


白芍中一种内生真菌Penicillium mariae-crucis的次生代谢产物研究

王举涛a, 马宗慧a, 王国凯a, 许凤清a, 郁阳b,c, 王刚a, 刘劲松a   

  1. a 安徽中医药大学药学院 现代中药安徽省重点实验室 合肥 230012;
    b 中国科学院大学 北京 100049;
    c 中国科学院昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室 昆明 650201
  • 收稿日期:2018-11-21 修回日期:2019-01-04 发布日期:2019-01-31
  • 通讯作者: 刘劲松
  • 基金资助:


Secondary Metabolites of Endophytic Fungus Penicillium mariae-crucis from Paeonia lactiflora Pall

Wang Jutaoaa, Ma Zonghuiaa, Wang Guokaiaa, Xu Fengqingaa, Yu Yangb,c, Wang Gangaa, Liu Jinsonga   

  1. a Anhui Key Laboratory for Modern Chinese Material Medical, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012;
    b University of Chinese Academy of Sciences, Beijing 100049;
    c State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201
  • Received:2018-11-21 Revised:2019-01-04 Published:2019-01-31
  • Contact: 10.6023/cjoc201811026
  • Supported by:

    Project supported by the Special Guide for Local Science and Technology Development Guided by the Central Committee of Anhui Province (No.2017070702D173),the Anhui University of Chinese Medicine (Nos.2017HXTS31,2017HXTS2) and the State Key Laboratory of Phytochemistry and Plant Resources in West China (No.P2017-KF03).

Four new compounds, penicmariae-crucis A (1), penicmariae-crucis B (2), penicmariae-crucis C (3), penicmariae-crucis D (4), and a new natural product, (E)-2-methylhex-3-enedioic acid (5), together with five known compounds, O-methylcurvulinic acid (6), methyl 2-acetyl-3-hydroxy-5-methoxyphenylacetate (7), methyl 2-acetyl-3,5-dihydroxyphenyl-acetate (8), β-sitosterol (9) and ergosterol peroxide (10), were isolated from the ethyl acetate extract of endophytic fungus Penicillium mariae-crucis in Paeonia lactiflora Pall. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from P. mariae-crucis for the first time.

Key words: P. lactiflora Pall, P. mariae-crucis, endophytic fungus, chemical constituent