Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1469-1474.DOI: 10.6023/cjoc201812046 Previous Articles     Next Articles



颜世强a,b, 郭伟b, 王文笙b, 张伟a   

  1. a 复旦大学药学院 上海 201203;
    b 山东达因海洋生物制药股份有限公司 威海 264300
  • 收稿日期:2018-12-26 修回日期:2019-01-16 发布日期:2019-01-31
  • 通讯作者: 张伟
  • 基金资助:


Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water

Yan Shiqianga,b, Guo Weib, Wang Wenshengb, Zhang Weia   

  1. a School of Pharmacy, Fudan University, Shanghai 201203;
    b Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300
  • Received:2018-12-26 Revised:2019-01-16 Published:2019-01-31
  • Contact: 10.6023/cjoc201812046
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81573340) and the Special Projects for Independent Innovation and Achievement Transformation of Shandong Province (No. 2015ZDXX0302A02).

Zinc-proline complex catalyzed Knoevenagel condensation in water was reported. Seventeen aldehydes and two ketones were investigated, which coupled with malononitrile smoothly affording desired Knoevenagel condensation products in 5~10 min at 80℃ in the yields of 84%~99%. The catalyst can be recovered and reused for ten cycles without loss of activity.

Key words: Knoevenagel condensation, aqueous media, zinc-proline complex, environmentally benign