Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola

doi:10.6023/cjoc201812009

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1475-1478.DOI: 10.6023/cjoc201812009 Previous Articles Next Articles

Notes

内生真菌叶下珠生拟茎点霉的次级代谢产物研究

刘洪新^a, 李浩华^a, 陈玉蝉^a, 谭海波^b, 章卫民^a

a 广东省微生物研究所省部共建华南应用微生物国家重点实验室广东省菌种保藏与应用重点实验室广东省微生物应用新技术公共实验室广州 510070;
b 中国科学院华南植物园广州 510650

收稿日期:2018-12-06 修回日期:2019-01-09 发布日期:2019-01-31
通讯作者: 章卫民 E-mail:wmzhang@gdim.cn
基金资助:
国家自然科学基金（No.31600271）、广东省科技计划（No.2107A020211023）和广州市珠江科技新星（No.201806010080）资助项目.

Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola

Liu Hongxin^a, Li Haohua^a, Chen Yuchan^a, Tan Haibo^b, Zhang Weimin^a

a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070;
b South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650

Received:2018-12-06 Revised:2019-01-09 Published:2019-01-31
Contact: 10.6023/cjoc201812009 E-mail:wmzhang@gdim.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 31600271), the Guangdong Provincial Project for Science and Technology (No. 2107A020211023), and the Pearl River Science and Technology New Star Fund of Guangzhou City (No. 201806010080).

1. Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola.PDF(834KB)

Abstract

The chemical investigation of the broth extract of the endophytic fungus Phomopsis phyllanthicola A658, which was isolated from the medicinal plant Pogostemon cablin, resulted in the isolation of one new compound, named dothiorelone O (1) and one new natural product 2-(3,5-dihydroxy-2-(7-hydroxyoctanoyl)phenyl)acetic acid (2), along with four known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. Moreover, all of the compounds were evaluated for in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines.

Key words: Pogostemon cablin, endophytic fungus, Phomopsis phyllanthicola, cytotoxicity

Cite this article

Liu Hongxin, Li Haohua, Chen Yuchan, Tan Haibo, Zhang Weimin. Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola[J]. Chin. J. Org. Chem., 2019, 39(5): 1475-1478.

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内生真菌叶下珠生拟茎点霉的次级代谢产物研究

Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola

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