Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (6): 1761-1766.DOI: 10.6023/cjoc201901015 Previous Articles     Next Articles

Special Issue: 金属有机化学 碳氢活化合辑2018-2019



王云龙a, 张林宝b, 牛俊龙a, 宋毛平a   

  1. a 郑州大学化学与分子工程学院 郑州 450001;
    b 青岛科技大学化学与分子工程学院 青岛 266042
  • 收稿日期:2019-01-11 修回日期:2019-02-25 发布日期:2019-03-08
  • 通讯作者: 牛俊龙, 宋毛平;
  • 基金资助:


Copper-Promoted Direct Nitration of Arenes Assisted by an N,O-Bidentate Directing System

Wang Yunlonga, Zhang Linbaob, Niu Junlonga, Song Maopinga   

  1. a College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001;
    b College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042
  • Received:2019-01-11 Revised:2019-02-25 Published:2019-03-08
  • Contact: 10.6023/cjoc201901015;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21772179, 21672192), the Program for Science & Technology Innovation Talents in Universities of Henan Province (No. 19HASTIT038).

Cu(Ⅱ)-promoted C-H nitration of arenes has been disclosed with the aid of N,O-bidentate directing group. The protocol was operationally simple by using NaNO2as the nitration source. Various amide substrates were tolerated in the reaction system, which establishes opportunities for developing simple and facile methods, and enriches the strategies to access aromatic nitro derivatives.

Key words: C-H activation, bidentate direction, Cu-catalyzed, nitration