Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (7): 1811-1830.DOI: 10.6023/cjoc201902019 Previous Articles     Next Articles

Reviews

N-苯氧基乙酰胺导向的碳氢键官能团化反应研究进展

姜晓蕾, 郝佳奇, 周国庆, 侯程程, 胡芳东   

  1. 临沂大学化学化工学院 临沂 276000
  • 收稿日期:2019-02-19 修回日期:2019-03-14 出版日期:2019-07-25 发布日期:2019-04-11
  • 通讯作者: 胡芳东 E-mail:hufangdong@lyu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21801109)、山东省自然科学基金(No.ZR2018BB019)、山东省高等学校科技计划(No.J17KA099)资助项目.

Recent Advances in N-Phenoxyacetamides Directed C-H Bond Functionalizations

Jiang Xiaolei, Hao Jiaqi, Zhou Guoqing, Hou Chengcheng, Hu Fangdong   

  1. School of Chemistry and Chemical Engineering, Linyi University, Linyi 276000
  • Received:2019-02-19 Revised:2019-03-14 Online:2019-07-25 Published:2019-04-11
  • Contact: 10.6023/cjoc201902019 E-mail:hufangdong@lyu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21801109), the Natural Science Foundation of Shandong Province (No. ZR2018BB019), and the Higher Educational Science and Technology Program of Shandong Province (No. J17KA099).

The C-H bond activation has become one of the hot fields of organic chemistry in recent years due to its atom economy and step simplicity. In the conventional C-H bond activations, an equivalent amount of oxidants is usually added to regenerate the catalyst and allow the catalytic cycle proceed smoothly. N-Phenoxyacetamide, as a novel reaction substrate containing an oxidizing directing group, can effectively avoid the use of an equivalent external oxidants. Thus, the C-H activation could be conducted under redox neutral conditions. In this paper, the latest research progress of N-phenoxyacetamides in the field of organic synthesis, especially C-H bond activations is reviewed, and the mechanism of the reaction is discussed.

Key words: N-phenoxyacetamides, internal oxidant, C-H bond activation, coupling partners