Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (6): 1529-1547.DOI: 10.6023/cjoc201904025 Previous Articles     Next Articles

Special Issue: 金属有机化学 碳氢活化合辑2018-2019



毛璞a, 朱军亮a, 袁金伟a, 杨亮茹a, 肖咏梅a, 张长森b   

  1. a 河南工业大学化学化工学院 河南省天然药物化学院士工作站 郑州 450001;
    b 郑州大学化学与分子工程学院 郑州 450001
  • 收稿日期:2019-04-10 修回日期:2019-04-24 发布日期:2019-05-06
  • 通讯作者: 袁金伟
  • 基金资助:


Recent Advances on the Catalytic Functionalization of Quinoxalin- 2(1H)-ones via C-H Bond Activation

Mao Pua, Zhu Junlianga, Yuan Jinweia, Yang Liangrua, Xiao Yongmeia, Zhang Changsenb   

  1. a Academician Workstation for Natural Medicinal Chemistry of Henan Province, School of Chemistry & Chemical Engineering, Henan Univeristy of Technology, Zhengzhou 450001;
    b College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
  • Received:2019-04-10 Revised:2019-04-24 Published:2019-05-06
  • Contact: 10.6023/cjoc201904025
  • Supported by:

    Project supported by the Department of Henan Province Natural Science and Technology Foundation (Nos. 172102210225 and 182102310675), the Natural Science Foundation in Henan Province Department of Education (No. 17A150005), the Program for Innovative Research Team from Zhengzhou (No. 131PCXTD605), and the Project of Youth Backbone Teachers of Henan University of Technology (No. 2016003).

Quinoxalin-2(1H)-ones are very important N-heterocyclic moieties found in natural products and pharmaceuticals, and exhibit an amazingly wide spectrum of biological properties. Numerous efforts have been devoted to the development of efficient approaches for the C-H bond activation and functionalization of quinoxalin-2(1H)-ones in recent years, including alkylation, benzylation, acylation, arylation,amination, amidation, phosphonation, and fluoroalkylation. The recent advances in this area are summarized and their reaction mechanisms are discussed.

Key words: quinoxalin-2(1H)-one, C-H bond activation, functionalization, transition-metal catalyst