Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2685-2704.DOI: 10.6023/cjoc201903058     Next Articles

REVIEW

二聚环色胺生物碱的全合成研究进展

沈先福ab, 彭天凤a, 周永云b, 奚永开b, 赵静峰b, 羊晓东b, 张洪彬b*()   

  1. a 曲靖师范学院 云贵高原化学功能材料与污染治理研究中心 生物资源与食品工程学院 云南曲靖 655011
    b 云南大学 云南省天然产物转化与利用及教育部自然资源药物化学重点实验室 昆明 650091
  • 收稿日期:2019-03-26 修回日期:2019-04-18 出版日期:2019-10-25 发布日期:2019-05-10
  • 通讯作者: 张洪彬 E-mail:zhanghb@ynu.edu.cn
  • 基金资助:
    长江学者和创新团队发展计划(IRT17R94);国家自然科学基金(2152197);国家自然科学基金(21861032);云南省自然科学基金(2018FD078);云南省自然科学基金(2017FH001-020);曲靖师范学院资助项目(2018QN002)

Progress in Total Syntheses of Dimeric Cyclotryptamine Alkaloids

Shen Xianfuab, Peng Tianfenga, Zhou Yongyunb, Xi Yongkaib, Zhao Jingfengb, Yang Xiaodongb, Zhang Hongbinb*()   

  1. a Center for Yunnan-Guizhou Plateau Chemical Functional Materials and Pollution Control, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing 655011, Yunnan
    b Key Laboratory of Natural Products Transformation and Utilization in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, Kunming 650091
  • Received:2019-03-26 Revised:2019-04-18 Online:2019-10-25 Published:2019-05-10
  • Contact: Zhang Hongbin E-mail:zhanghb@ynu.edu.cn
  • Supported by:
    Project supported by the Program for Changjiang Scholars and Innovative Research Team in University(IRT17R94);The National Natural Science Foundation of China(2152197);The National Natural Science Foundation of China(21861032);The Natural Science Foundation of Yunnan Province(2018FD078);The Natural Science Foundation of Yunnan Province(2017FH001-020);The Qujing Normal University(2018QN002)

As interesting synthetic targets, dimeric cyclotryptamine alkaloids bearing sterically hindered vicinal all-carbon quaternary stereocenters have attracted significant attention from the synthetic community. Stereocontrolled synthesis of the congested all-carbon quaternary stereocenters in these alkaloids presents a formidable challenge. This review summarizes the synthetic efforts towards dimeric cyclotryptamine alkaloids in the last twelve years.

Key words: dimeric cyclotryptamine, alkaloids, vicinal quaternary carbons, oxindole, total synthesis