Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (8): 2614-2627.DOI: 10.6023/cjoc202302010 Previous Articles     Next Articles


王玉超a,b,c, 刘晋彪a,*(), 何智涛b,c,*()   

  1. a 江西理工大学材料冶金化学学部 江西赣州 341000
    b 中国科学院上海有机化学研究所 中国科学院天然产物有机合成化学重点实验室 上海 200032
    c 中国科学院大学 北京 100049
  • 收稿日期:2023-02-11 修回日期:2023-03-18 发布日期:2023-04-07
  • 基金资助:
    国家自然科学基金(22071262); 上海市科学技术委员会(22ZR1475200); 上海市启明星计划(20QA1411300)

Palladium-Catalyzed Asymmetric Hydrofunctionalizations of Conjugated Dienes

Yuchao Wanga,b,c, Jinbiao Liua(), Zhitao Heb,c()   

  1. a Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Science and Technology, Ganzhou, Jiiangxi 341000
    b CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Shanghai 200032
    c University of Chinese Academy of Sciences, Beijing 100049
  • Received:2023-02-11 Revised:2023-03-18 Published:2023-04-07
  • Contact: *;
  • Supported by:
    The National Natural Science Foundation of China(22071262); The Science and Technology Commission of Shanghai Municipality(22ZR1475200); The Shanghai Rising-Star Program(20QA1411300)

Because of the broad substrate availability, high atom economy and efficient stereocontrol, palladium-catalzyed asymmetric hydrofunctionalizations of conjugated dienes have emerged as an efficient route to construct enantioenriched allylic motifs, including allylic C—C, C—N, C—S, C—P, C—Si and C—O bonds. The development, advance and mechanistic features of this area in the past decades are summarized. Based on the types of allylic stereogenic centers constructed via this strategy, the review is divided into six parts, including asymmetric hydroalkylation, hydroamination, hydrophosphinylation, hydrosulfonylation, hydrosilylation and hydroalkoxylation.

Key words: palladium catalysis, conjugated dienes, hydrofunctionalization, asymmetric synthesis