Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (5): 1096-1104.DOI: 10.6023/cjoc201912025 Previous Articles     Next Articles

Special Issue: 镍催化有机反应合辑

镍催化均相不对称氢化反应研究进展

刘元华a, 董秀琴a, 张绪穆b   

  1. a 武汉大学化学与分子科学学院 生物医用高分子材料教育部重点实验室 有机硅化合物及材料教育部工程中心 武汉 430072;
    b 南方科技大学化学系 广东深圳 518055
  • 收稿日期:2019-12-19 修回日期:2020-01-20 出版日期:2020-05-25 发布日期:2020-02-15
  • 通讯作者: 董秀琴 E-mail:xiuqindong@whu.edu.cn
  • 基金资助:
    国家自然科学基金(No.21502145)、武汉市青年科技晨光计划(No.2017050300307)和江苏省自然科学基金(No.SBK2019041078)资助项目.

Recent Advances of Nickel-Catalyzed Homogeneous Asymmetric Hydrogenation

Liu Yuanhuaa, Dong Xiu-Qina, Zhang Xumub   

  1. a Key Laboratory of Biomedical Polymers, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072;
    b Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong 518055
  • Received:2019-12-19 Revised:2020-01-20 Online:2020-05-25 Published:2020-02-15
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21502145), the Wuhan Morning Light Plan of Youth Science and Technology (No. 2017050300307) and the National Natural Science Foundation of Jiangsu Province (No. SBK2019041078).

Transition metal complexes-catalyzed homogeneous asymmetric hydrogenation is an important method for the synthesis of chiral compounds. At present, it is mainly focused on precious transition metal catalytic systems, such as ruthenium, rhodium, iridium and palladium. However, they are suffered from the difficulties of limited resource, high cost and environmental contamination. Therefore, it is important and necessary to develop catalytic systems based on cheap, non-toxic or low toxic, environmentally friendly and earth-abundant iron, cobalt, nickel, copper transition metal, which are in accordance with the requirements and research trend of the sustainable development of modern chemistry. The recent progress of nickel-catalyzed homogeneous asymmetric hydrogenation of prochiral unsaturated compounds containing carbon oxygen double bond (C=O), carbon carbon double bond (C=C) and carbon nitrogen double bond (C=N) is reviewed, and some breakthroughs and considerable research results achieved are introduced. In addition, the advantages and disadvantages of different types of substrates in nickel catalyst system are analyzed, and the future research direction is prospected.

Key words: asymmetric hydrogenation, nickel catalysis, chiral diphosphine ligand, chiral compounds, stereoselectivity