Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3196-3202.DOI: 10.6023/cjoc202005056 Previous Articles     Next Articles


李然a,b, 徐学涛a, 叶萌春a,b   

  1. a 五邑大学生物科技与大健康学院 广东江门 529020;
    b 南开大学化学学院 元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2020-05-21 修回日期:2020-06-10 发布日期:2020-06-20
  • 通讯作者: 徐学涛, 叶萌春;
  • 基金资助:

Construction of Medium Rings via Transition Metal-Catalyzed Insertion of π-Unsaturated Compounds into C—H Bonds

Li Rana,b, Xu Xuetaoa, Ye Mengchuna,b   

  1. a School of Biotechnology and Health Science, Wuyi University, Jiangmen, Guangdong 529020;
    b State Key Laboratory and Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
  • Received:2020-05-21 Revised:2020-06-10 Published:2020-06-20
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21672107, 21871145, 91856104) and the Department of Education of Guangdong Province (No. 2019KZDXM035).

Medium rings (7~9 membered) widely exist in a variety of natural products that often have important bio-activities, thereby the development of economical and highly efficient synthetic routes to them has received intensive attention. Recent advances on transition metal-catalyzed π-unsaturated compounds inserting into C-H bonds for the construction of medium rings are summarized. According to different strategies that were used to stabilize organometallic intermediates, these methods can be divided into four types, and each of which was described from various aspects including its progress, characteristics, reaction types and mechanisms.

Key words: medium-ring compound, transition metal catalysis, π-unsaturated bond, C-H bond