Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (3): 934-946.DOI: 10.6023/cjoc202008017 Previous Articles     Next Articles

Special Issue: 有机氟化学合辑



刘颖杰1, 韩莹徽1, 林立青1, 许颖1,*()   

  1. 1 哈尔滨商业大学药学院 哈尔滨 150076
  • 收稿日期:2020-09-11 修回日期:2020-09-22 发布日期:2020-10-15
  • 通讯作者: 许颖
  • 基金资助:

Research Progress of Polyfluoroalkylation Reaction under Electrochemical Catalysis

Yingjie Liu1, Yinghui Han1, Liqing Lin1, Ying Xu1,*()   

  1. 1 School of Pharmacy, Harbin University of Commerce, Harbin 150076
  • Received:2020-09-11 Revised:2020-09-22 Published:2020-10-15
  • Contact: Ying Xu
  • About author:
    * Corresponding author. E-mail:
  • Supported by:
    Youth Reserve Talent Project of Harbin Business University(2019CX36)

Fluorine chemistry has been widely used in all walks of life, and the combination of fluorine chemistry and organic chemistry is blooming everywhere. Since the introduction of fluorine atoms or fluorine groups into drugs is of great significance, it is essential to seek an effective fluoroalkylation pathway. With the development of electrochemistry, people combine electrochemistry and fluoroalkylation reaction skillfully. In turn, a safer, more economical, environmentally friendly and efficient fluoroalkylation pathway is obtained. The fluoroalkylation reaction pathway under the guidance of electrochemistry has not only reformed the reaction method, but also has advantages in terms of substrate universality. Fluoroalkylation of unsaturated aliphatic compounds their derivatives and aromatic compounds under electrochemical catalysis has been reported. According to the nature of the substrate and its reaction mechanism, the progress of electrocatalytic fluoroalkylation methods is summarized.

Key words: electrochemistry, fluorochemistry, fluoroalkylation reaction, olefin, aromatic