Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (6): 2228-2248.DOI: 10.6023/cjoc202010039 Previous Articles     Next Articles



底慧明(), 刘云婷, 马艳榕, 杨鑫悦, 金辉*(), 张立新*()   

  1. 沈阳化工大学功能分子研究所 辽宁省绿色功能分子设计与开发重点实验室 沈阳市靶向农药重点实验室 沈阳 110142
  • 收稿日期:2020-10-28 修回日期:2020-11-18 发布日期:2021-02-22
  • 通讯作者: 金辉, 张立新
  • 基金资助:
    辽宁省教育厅科学研究(LQ2020025); 南宁市科学研究与技术开发计划(20201043)

Recent Advances in Organocatalytic Asymmetric Synthesis of 3,4-Dihydropyran-2-ones and 3,4-Dihydropyridin-2-ones

Huiming Di(), Yunting Liu, Yanrong Ma, Xinyue Yang, Hui Jin(), Lixin Zhang()   

  1. Shenyang Key Laboratory of Targeted Pesticides, Liaoning Key Laboratory of Green Functional Molecular Design and Development, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang 110142
  • Received:2020-10-28 Revised:2020-11-18 Published:2021-02-22
  • Contact: Hui Jin, Lixin Zhang
  • Supported by:
    Science and Technology Project of Liaoning Education Department(LQ2020025); Nanning Scientific Research and Technology Development Program(20201043)

3,4-Dihydropyranone and 3,4-dihydropyridinone substructures are widely found in a variety of natural products and pharmacologically active molecules, so the efficient synthesis of chiral 3,4-dihydropyranones and 3,4-dihydropyridinones has received more and more attention from pharmaceutical chemists and organic chemists. In recent years, organocatalytic asymmetric reaction has become an efficient synthetic method for the construction of chiral heterocyclic compounds. In this review, the remarkable progress and advances in organocatalytic asymmetric reactions for the synthesis of 3,4-dihydro- pyranones and 3,4-dihydropyridinones from 2003 to 2020 are summarized and discussed based on the different types of organocatalysts and reaction mechanisms.

Key words: organocatalysis, asymmetric catalysis, 3,4-dihydropyranones, 3,4-dihydropyridinones