Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (7): 2636-2649.DOI: 10.6023/cjoc202101041 Previous Articles     Next Articles



肖检a, 彭羽a,b, 李卫东a,b,*()   

  1. a 西南交通大学生命科学与工程学院 四川省天然药物仿生合成工程研究中心 成都 610031
    b 伊犁师范大学 新疆天然产物化学与应用重点实验室 新疆伊宁 835000
  • 收稿日期:2021-01-25 修回日期:2021-02-21 发布日期:2021-03-12
  • 通讯作者: 李卫东
  • 基金资助:
    国家自然科学基金(21772078); 中央高校基本科研业务费专项资金(2682019CX70); 中央高校基本科研业务费专项资金(2682019CX71); 中央高校基本科研业务费专项资金(2682020CX55); 新疆维吾尔自治区高校科研计划项目(重点项目)(XJEDU2018I018)

Advances on the Total Synthesis of Sesquiterpenoid Alkaloid Dendrobine

Jian Xiaoa, Yu Penga,b, Wei-Dong Z. Lia,b()   

  1. a Engineering Research Center Biomimetic Synthesis of Natural Drugs of Sichuan Province, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    b Key Lab of Natural Product Chemistry and Application in Xinjiang, Yili Normal University, Yining, Xinjiang 835000
  • Received:2021-01-25 Revised:2021-02-21 Published:2021-03-12
  • Contact: Wei-Dong Z. Li
  • Supported by:
    National Natural Science Foundation of China(21772078); Fundamental Research Funds for the Central Universities(2682019CX70); Fundamental Research Funds for the Central Universities(2682019CX71); Fundamental Research Funds for the Central Universities(2682020CX55); Program of Natural Science Foundation of Xinjiang Autonomous Region Colleges (Key Program)(XJEDU2018I018)

Dendrobine is an important sesquiterpenoid alkaloid bearing the picrotoxane carbon skeleton isolated from the traditional Chinese medicine “Chin-Shih-Hu”. Because of structural characteristics of fused polycyclic and seven contiguous stereocenters, and exhibiting analgesic, antipyretic activities, dendrobine has attracted a great deal of attentions from both synthetic organic chemists and medicinal chemists. Over the past 50 years, there has been a number of research reports on the pharmacological activities and chemical synthesis of dendrobine. This review summarizes the biosynthetic hypothesis and synthetic advances on dendrobine.

Key words: natural product, sesquiterpenoid alkaloid, dendrobine, total synthesis, picrotoxane