Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (8): 2933-2945.DOI: 10.6023/cjoc202103048 Previous Articles     Next Articles



赵军a, 肖检a,*(), 王雅雯a, 彭羽a,b,*()   

  1. a 西南交通大学生命科学与工程学院 四川省天然药物仿生合成工程研究中心 成都 610031
    b 伊犁师范大学化学与环境科学学院 新疆伊宁 835000
  • 收稿日期:2021-03-26 修回日期:2021-04-21 发布日期:2021-05-14
  • 通讯作者: 肖检, 彭羽
  • 基金资助:
    国家自然科学基金(21772078); 国家自然科学基金(22071200); 四川省科技计划(2020JDRC0021); 中央高校基本科研业务费专项资金(2682020CX55)

Advances on the Synthesis of Natural Products with Dihydrobenzofuran Skeleton via Oxidative [3+2] Cycloadditions

Jun Zhaoa, Jian Xiaoa(), Yawen Wanga, Yu Penga,b()   

  1. a Engineering Research Center of Biomimetic Synthesis of Natural Drugs of Sichuan Province, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    b School of Chemistry and Environment Science, Yili Normal University, Yining, Xinjiang 835000
  • Received:2021-03-26 Revised:2021-04-21 Published:2021-05-14
  • Contact: Jian Xiao, Yu Peng
  • Supported by:
    National Natural Science Foundation of China(21772078); National Natural Science Foundation of China(22071200); Science and Technology Department of Sichuan Province(2020JDRC0021); Fundamental Research Funds for the Central Universities(2682020CX55)

Dihydrobenzofuran structure units widely exist in a variety of natural products, such as alkaloids and terpenes. The total synthesis of natural products containing dihydrobenzofuran skeleton has thus emerged in recent years, because of their good biological activities and medicinal value. The application progress of oxidative [3+2] cycloaddition in the construction of dihydrobenzofuran ring skeleton and the total synthesis of various natural products in recent ten years was reviewed.

Key words: oxidative [3+2] cycloaddition, dihydrobenzofuran, natural product, total synthesis, biomimetic synthesis