Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (10): 3771-3791.DOI: 10.6023/cjoc202104024 Previous Articles     Next Articles



董建洋, 刘玉秀, 汪清民*()   

  1. 南开大学化学学院 元素有机化学国家重点实验室 南开大学有机新物质创造前沿科学中心 天津 300071
  • 收稿日期:2021-04-12 修回日期:2021-05-04 发布日期:2021-06-02
  • 通讯作者: 汪清民
  • 基金资助:
    国家自然科学基金(21732002); 国家自然科学基金(22077071); 南开大学有机新物质创造前沿科学中心专项资金(63181206)

Recent Advances in Visible-Light-Mediated Minisci Reactions

Jianyang Dong, Yuxiu Liu, Qingmin Wang()   

  1. State Key Laboratory of Elemento-organic Chemistry, Frontiers Science Center for New Organic Matter of Nankai University, College of Chemistry, Nankai University, Tianjin 300071
  • Received:2021-04-12 Revised:2021-05-04 Published:2021-06-02
  • Contact: Qingmin Wang
  • Supported by:
    National Natural Science Foundation of China(21732002); National Natural Science Foundation of China(21672117); Frontiers Science Center for New Organic Matter of Nankai University(63181206)

N-Heteroarenes are present in a wide variety of natural products, small-molecule drugs, organic materials, and ligands. Therefore, the methods for selective C—H functionalization of N-heteroarenes are highly sought-after for late-stage modification of pharmaceuticals. A useful tool for the synthesis of alkyl-substituted nitrogen-containing aromatic rings is the Minisci reaction, in which a protonated N-heteroarene is attacked by an alkyl radical under oxidative and acidic conditions. Classic Minisci reactions often require the use of excess oxidant, excess acid, and high temperature, which greatly limits the scope of the substrates. With the rapid development of photocatalysis in organic synthesis, in recent years, a variety of photocatalytic Minisci reactions have been reported, and successfully been applied to the synthesis of drugs. In this paper, the visible light mediated Minisci reactions in recent years are briefly reviewed.

Key words: N-heteroarenes, Minisci reaction, alkyl radical, photocatalysis