Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (9): 3414-3430.DOI: 10.6023/cjoc202104058 Previous Articles     Next Articles



陈伟a,b, 刘强a,*()   

  1. a 南方医科大学中医药学院 广州 510515
    b 粤澳中医药科技产业园开发有限公司 广东珠海 519031
  • 收稿日期:2021-04-28 修回日期:2021-05-10 发布日期:2021-06-17
  • 通讯作者: 刘强
  • 基金资助:

Recent Advances in the Oxidative Coupling Reaction of Enol Derivatives

Wei Chena,b, Qiang Liua()   

  1. a School of Chinese Medicine, Southern Medicinal University, Guangzhou 510515
    b Guangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co., Ltd., Zhuhai, Guangdong 519031
  • Received:2021-04-28 Revised:2021-05-10 Published:2021-06-17
  • Contact: Qiang Liu
  • Supported by:
    China Postdoctoral Science Foundation(2020M682925)

Oxidative coupling reaction of enol derivatives (enolates, enol silanes, enamines, etc.) provides an efficient method for the direct construction of carbon-carbon bond, which plays a prominent role in the field of synthetic chemistry. Although the first case of this reaction had been reported in 1935, it was not until the 1970s that chemists began to pay more attention to this reaction. However, the effectiveness and practicability of this reaction were still somewhat limited at that time. In recent years, this reaction has been developed rapidly in the field of synthetic methodology and the total synthesis of natural products. Therefore, these advances in methodologies and its applications in the total synthesis of natural products in the last decades are mainly summarized.

Key words: oxidative coupling reaction, enol derivatives, carbon-carbon bond, methodology, natural product