Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (3): 742-757.DOI: 10.6023/cjoc202109045 Previous Articles     Next Articles



陈宏超a,b, 吴奕晨b, 于洋a, 王鹏b,c,d,*()   

  1. a 上海大学理学院 上海 201900
    b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
    c 中国科学院上海有机化学研究所 中国科学院能量调控材料重点实验室 上海 200032
    d 中国科学院大学杭州高等研究院 化学与材料科学学院 杭州 310024
  • 收稿日期:2021-09-28 修回日期:2021-11-03 发布日期:2021-11-17
  • 通讯作者: 王鹏
  • 基金资助:
    国家自然科学基金(22171277); 国家自然科学基金(22101291); 国家自然科学基金(21821002); 上海“启明星”(20QA1411400)

Pd-Catalyzed Isomerization of Alkenes

Hong-Chao Chena,b, Yichen Wub, Yang Yua, Peng Wangb,c,d()   

  1. a College of Science, Shanghai University, Shanghai 201900
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032
    c CAS Key Laboratory of Energy Regulation Materials, Shanghai Institute of Organic Chemistry, Shanghai 200032
    d School of Chemistry and Material Sciences, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024
  • Received:2021-09-28 Revised:2021-11-03 Published:2021-11-17
  • Contact: Peng Wang
  • Supported by:
    National Natural Science Foundation of China(22171277); National Natural Science Foundation of China(22101291); National Natural Science Foundation of China(21821002); Shanghai Rising-Star Program(20QA1411400)

Starting from commercially available simple olefins, alkene isomerization could realize the efficient construction of multi-substituted alkenes, which might be difficult to access with other synthetic methods, in an atom-economic manner via the stereoselective or positional-selective modulation of the carbon-carbon double bonds. The palladium catalyzed stereoselective (Z/E) and the positional selective isomerization reactions of alkenes are summarized. The mechanistic perspectives, and their synthetic applications in the synthesis of drug molecules and natural products are discussed in detail.

Key words: palladium catalysis, alkene, carbon-carbon bond, isomerization