Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (10): 3792-3807.DOI: 10.6023/cjoc202106002 Previous Articles     Next Articles



张建明, 高健, 冯捷, 陆涛*(), 杜鼎*()   

  1. 中国药科大学理学院化学系 天然药物活性组分与药效国家重点实验室 南京 210009
  • 收稿日期:2021-06-01 修回日期:2021-07-02 发布日期:2021-08-17
  • 通讯作者: 陆涛, 杜鼎
  • 基金资助:
    国家自然科学基金(21572270); 国家自然科学基金(21702232); “双一流”建设高校(CPU2018GY02); “双一流”建设高校(CPU2018GY35); 中央高校基本科研业务费专项资金(2632021ZD19)

Recent Advances in Synergistic Catalysis by Merging N-Heterocyclic Carbenes and Transition Metals

Jianming Zhang, Jian Gao, Jie Feng, Tao Lu(), Ding Du()   

  1. State Key Laboratory of Natural Medicines, Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing 210009
  • Received:2021-06-01 Revised:2021-07-02 Published:2021-08-17
  • Contact: Tao Lu, Ding Du
  • Supported by:
    National Natural Science Foundation of China(21572270); National Natural Science Foundation of China(21702232); “Double First-Class” University Project(CPU2018GY02); “Double First-Class” University Project(CPU2018GY35); Fundamental Research Funds for the Central Universities(2632021ZD19)

Unique reaction modes, diverse reaction sites, and structural diversity of both substrates and products have made N-heterocyclic carbene catalysis be of great of importance in the field of organic catalysis. However, there have been a lot of barriers and challenges in terms of the reactivity of substrates and the selectivity of reactions for traditional and single catalytic systems with the deep development of organic synthesis. Recently, synergistic catalysis makes it possible for previously inaccessible transformations and can adjust the reactivity and selectivity more accurately by merging two single catalytic systems, thus has emerged as a powerful catalytic strategy in organic synthesis. In this review, the latest research progress in the field of synergistic catalysis of N-heterocyclic carbenes and transition metals in the last decade is mainly reviewed.

Key words: N-heterocyclic carbene catalysis, transition metal catalysis, synergistic catalysis, asymmetric synthesis