Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (1): 16-32.DOI: 10.6023/cjoc202108043 Previous Articles     Next Articles



吴锦涛, 柳忠全*()   

  1. 南京中医药大学药学院 南京 210023
  • 收稿日期:2021-08-23 修回日期:2021-09-17 发布日期:2021-09-26
  • 通讯作者: 柳忠全
  • 基金资助:

Advances in Free-Radical Promoted C(sp3)—C(sp3) Bond Conversion

Jintao Wu, Zhongquan Liu()   

  1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023
  • Received:2021-08-23 Revised:2021-09-17 Published:2021-09-26
  • Contact: Zhongquan Liu
  • Supported by:
    National Natural Science Foundation of China(21971116)

Efficient C—C bond conversion might bring innovation to clean energy and circular economy. In the past several decades, developments of relatively chemical active carbon-carbon multibond conversion have been made. However, the research progress on effective functionalization of inert C(sp3)—C(sp3) bond is heavy going. The advances in this area from a free-radical chemistry point of view are summarized, which can help researchers who are interested in this topic to understand it quickly. The progesses as well as the corresponding mechanisms for free-radical promoted selective cleavage of saturated C—C bonds in alcohols and ethers, amines, aryl alkanes and simple alkanes are demonstrated. In each part, the explorations are depicted according to the initiating manners such as thermochemistry, photochemistry and electrochemistry.

Key words: free-radical chemistry, C—C bond activation, photochemistry, electrochemistry, alcohol and ether, amine, aryl alkane, simple alkane