Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (12): 4780-4788.DOI: 10.6023/cjoc202109029 Previous Articles     Next Articles



涂志, 赵保丽, 万结平, 王超莉*(), 刘云云*()   

  1. 江西师范大学化学化工学院 南昌 330022
  • 收稿日期:2021-09-18 修回日期:2021-10-14 发布日期:2021-10-20
  • 通讯作者: 王超莉, 刘云云
  • 基金资助:

Aerobic Construction of 2-Acyl Benzoxazole by Tandem C—H Oxygenation and Oxazole Ring Formation

Zhi Tu, Baoli Zhao, Jieping Wan, Chaoli Wang(), Yunyun Liu()   

  1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022
  • Received:2021-09-18 Revised:2021-10-14 Published:2021-10-20
  • Contact: Chaoli Wang, Yunyun Liu
  • Supported by:
    Natural Science Foundation of Jiangxi Province(20202BABL203008)

The synthesis of useful 2-acyl benzoxazoles has been realized via the tandem methylene C—H oxygenation and oxazole annulation of N-(o-hydroxyphenyl)phenylacetamides via copper catalysis in one-pot fashion. Besides featuring the incomparable step-economy resulting from the multi-step transformation, the tunable synthesis of diverse 2-methylene functionalized benzoxazoles using identical starting materials as well as the expanded synthesis of corresponding benzothiazoles is also attractive advantage of the work.

Key words: tandem, C—H oxygenation, annulation, 2-acyl benzoxazole, selectivity