Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (12): 4712-4717.DOI: 10.6023/cjoc202111010 Previous Articles     Next Articles



吴红谕a, 于贤勇b,*(), 曹忠a,*()   

  1. a 长沙理工大学化学化工学院 电力与交通材料保护湖南省重点实验室&细胞化学湖南省重点实验室 长沙 410114
    b 湖南科技大学化学化工学院 理论有机化学与功能分子教育部重点实验室 湖南湘潭 411201
  • 收稿日期:2021-11-04 修回日期:2021-12-09 发布日期:2021-12-15
  • 通讯作者: 于贤勇, 曹忠
  • 基金资助:
    国家自然科学基金(21545010); 湖南省自然科学基金(2020JJ4599); 湖南省科技创新计划(2021RC5028)

Electrochemical Multicomponent Synthesis of α-Ketoamides from α-Oxocarboxylic Acids, Isocyanides and Water

Hongyu Wua, Xianyong Yub(), Zhong Caoa()   

  1. a Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114
    b Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201
  • Received:2021-11-04 Revised:2021-12-09 Published:2021-12-15
  • Contact: Xianyong Yu, Zhong Cao
  • Supported by:
    National Natural Science Foundation of China(21545010); Natural Science Foundation of Hunan Province(2020JJ4599); Science and Technology Innovation Program of Hunan Province(2021RC5028)

Electrochemical organic synthesis is considered as an environmentally benign method because it employs traceless electrons as redox agents, thereby avoiding the need for chemical oxidants. The electrochemical decarboxylative acylation of isocyanides and relay hydration reaction for the synthesis of α-ketoamides was developed. This reaction can be carried out under mild conditions in the absence of a chemical oxidant and a transition-metal catalyst.

Key words: electrochemical synthesis, decarboxylative acylation, hydration reaction, isocyanide, α-ketoamides