Preparation of water soluble fullerenes (C₆₀) derivatives is meaningful to biological study of fullerenes. Amination reaction of amino-acid with C₆₀ led to water soluble amino-acid C₆₀ derivatives. Reaction of C₆₀ with excess of NH₂(CH₂)₅COO^－Na⁺ (1) or (4) (molar ratio is 1∶10) at 80 ℃ for 24 h afforded main amino-acid C₆₀ adducts with addition degree of 5 and 4, respectively. The yields based on the C₆₀ added were 30% and 28%, respectively. The addition degree was influenced by the length of hydrocarbon chain of amino-acid and precipitation of C₆₀ adducts from the reactant. C₆₀[NH(CH₂)₅- COOH]₅H₅ (3a) and C₆₀(NHCH₂CH₂SO₃H)₄H₄ (6a) were further purified by silica column chromatography and characterized by ¹H NMR, ¹³C NMR, IR, FAB-MS spectra and elemental analysis. The solubility of 6a was less pH dependent. The solubility of 3a in water at different pH was measured by the spectro-photometric method, exhibiting solubility of 71.81 mg•mL^－1 (pH＝10.25), 23.68 mg•mL^－1 (pH＝7) and 10.12 mg•mL^－1 (pH＝3.36). The ε value of 3a at 272.8 nm was 3.43×10⁴ L•mol^－1•cm^－1.

Key words: 6-aminohexanoic acid, 2-aminoethanesulfonic acid, amination, fullerene