Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (10): 1836-1840. Previous Articles     Next Articles



谭成侠*,a ; 潘丽艳a ; 丁成荣a ; 来虎钦a ;
翁建全a; 周 瑛a ; 欧晓明b

  1. (a浙江工业大学化学工程与材料学院 杭州 310032)
    (b国家南方农药创制中心湖南基地生测部 长沙 410007)
  • 收稿日期:2007-12-31 修回日期:2008-04-03 发布日期:2008-10-20
  • 通讯作者: 谭成侠*,

Synthesis and Fungicidal Activities of 1-[(Un)substituted phenyl]-4-(pyrazol-5-ylcarbony)semicarbazide

TAN, Cheng-Xia*,a ; PAN, Li-Yana; DING, Cheng-Rong a; LAI, Hu-Qin a;
WENG, Jian-Quana ; ZHOU, Yinga ; OU, Xiao-Mingb

  1. (a College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014)
    (b Bioassay Department, Hunan Branch of National Southern Pesticide Research Centre, Changsha 410007)
  • Received:2007-12-31 Revised:2008-04-03 Published:2008-10-20
  • Contact: TAN, Cheng-Xia

In order to find new pyrazole leading compounds, 14 1-[(un)substituted phenyl]-4-(pyrazol- 5-ylcarbony)semicarbazide devivatives were synthesized from 4-chloro-3-ethyl-1-methyl-5-pyrazole car-bonydrazide and substituted phenylisocyanate. The structures of all the new compounds were confirmed by 1H NMR, IR, MS and elemental analysis. The preliminary bioassays indicated that, at 500 (g/mL, 1-(o-tolyl)-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonyl)semicarbazide (4g) and 1-(2,4-dimethyl- phenyl)-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonyl)semicarbazide (4k) showed inhibitory activities 90% and 80% against Blumeria graminis, respectively; and at 25 (g/mL, 4-phenyl-4-(4-chloro-3-ethyl-1- methylpyrazol-5-ylcarbonyl)semicarbazide (4c) showed inhibitory activity 70.1% against Botrytis cinerea and 1-(2-nitro-phenyl-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonyl)semicarbazide (4d) showed inhibi-tory activitiy 51.3% against Pyricularia oryzae.

Key words: semicarbazide, pyrazole, fungicidal activity