Proline/CuI Catalyzed Heck Reaction in Aqueous Two-Phase System

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (01): 60-65. Previous Articles Next Articles

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双水相体系中Proline/CuI催化Heck反应的研究

郭圣荣*，袁艳琴，王艳，郑云法

(丽水学院化学与生命学院丽水 323000)

收稿日期:2009-02-23 修回日期:2009-04-17 发布日期:2010-01-20
通讯作者: 郭圣荣 E-mail:guosr9608@163.com

Proline/CuI Catalyzed Heck Reaction in Aqueous Two-Phase System

Guo,Shengrong*，Yung,Yanqin，Wang,Yan，Zheng,Yunfa

(Department of Chemistry，Lishui College，Lishui 323000)

Received:2009-02-23 Revised:2009-04-17 Published:2010-01-20

Abstract

The copper-catalyzed Heck reaction of acrylic ester or styrene with aryl halide gave the coupling products in good to excellent yields in aqueous two-phases system in 75～85 ℃ by using L-proline as a ligand。This method provides a new simple and inexpensive access to the Heck reaction。The structures of the products were confirmed by using spectroscopic techniques such as IR，1H NMR，13C NMR and comparing their melting points with known literature.

Key words: aqueous two-phase system, Heck reaction, aryl halide, L-proline, CuI

Cite this article

GUO Ku-Rong, YUAN Yan-Qin, WANG Yan, ZHENG Yun-Fa. Proline/CuI Catalyzed Heck Reaction in Aqueous Two-Phase System[J]. Chin. J. Org. Chem., 2010, 30(01): 60-65.

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双水相体系中Proline/CuI催化Heck反应的研究

Proline/CuI Catalyzed Heck Reaction in Aqueous Two-Phase System

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