Spectroscopy Studies of Interactions between DNA and N3O2-Donor Macrocycle Bearing Naphathalic Sulfonic Group

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (01): 66-71. Previous Articles Next Articles

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含萘磺酰基N3O2大环化合物与DNA相互作用的光谱法研究

陈稼轩，田怡，向清祥*，张丽群，熊俊如

(乐山师范学院化学与生命科学学院乐山 614004)

收稿日期:2009-03-25 修回日期:2009-06-25 发布日期:2010-01-20
通讯作者: 向清祥 E-mail:qxxiang711@163.com; xqxiang711@yahoo.com.cn
基金资助:
四川高校重点实验室专项（NO. 2006ZD049）;四川省教育厅（NO. 07ZC023）;乐山师范学院（NO. Z07045）项目

Spectroscopy Studies of Interactions between DNA and N3O2-Donor Macrocycle Bearing Naphathalic Sulfonic Group

Chen,Jiaxuan，Tian,Yi，Xiang,Qingxiang*，Zhang,Liqun，Xiong,Junru

(Department of Chemistry and Life Science，Leshan Teachers College，Leshan 614004)

Received:2009-03-25 Revised:2009-06-25 Published:2010-01-20

Abstract

A N3O2-donor macrocycle bearing a naphathalic sulfonic group derived from 8,11,14-triaza-5,6: 16,17-dibenzo-1,4-dioxacycloheptadecane has been synthesized，and its structure was characterized by 1H NMR，MS data and elemental analysis。The interactions of the target compound with CT (calf thymus) DNA have been investigated by the ultraviolet spectrophotometry and fluorescence spectrophotometry。The results showed that the binding model between the N3O2-donor macrocycle and CT DNA was intercalation，with the binding constants being ＝20706.9 dm3•mol－1 and ＝12416.9 dm3•mol－1。The com-bination was the enthalpy driven reaction.

Key words: N3O2-donor macrocycle, synthesis, CT DNA, spectrum

Cite this article

CHEN Jia-Han, TIAN Yi, XIANG Qing-Xiang, ZHANG Li-Qun, XIONG Dun-Ru. Spectroscopy Studies of Interactions between DNA and N3O2-Donor Macrocycle Bearing Naphathalic Sulfonic Group[J]. Chin. J. Org. Chem., 2010, 30(01): 66-71.

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含萘磺酰基N3O2大环化合物与DNA相互作用的光谱法研究

Spectroscopy Studies of Interactions between DNA and N3O2-Donor Macrocycle Bearing Naphathalic Sulfonic Group

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