Progress of Julia Olefination in Total Synthesis of Natural Products

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (11): 1615-1623. Previous Articles Next Articles

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Julia烯烃合成法在天然产物全合成中的应用新进展

马俊海¹，王帆¹，王进欣*^{,1，尤启冬*^,2}

(¹中国药科大学药学院药物化学教研室南京 210009)
(²江苏省肿瘤发生与干预重点实验室南京 210009)

收稿日期:2009-10-31 修回日期:2010-04-09 发布日期:2010-04-30
通讯作者: 王进欣 E-mail:jinxinwang@163.com
基金资助:
国家级.国家自然科学基金

Progress of Julia Olefination in Total Synthesis of Natural Products

Ma Junhai¹ Wang Fan¹ Wang Jinxin*^{,1 You Qidong*^,2}

(¹ Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009)
(²Key Laboratopry of Carcinogesis and Intervention of Jiangsu Province, Nanjing 210009)

Received:2009-10-31 Revised:2010-04-09 Published:2010-04-30

Abstract

Julia ole?nation with certain heteroarylsulfones and the corresponding conditions controlling the reaction profoundly alters the reaction manifold, which has been applicated crucially in total synthesis of natural products. This review focuses on the progress of Julia olefination (including Julia-Lythgoe reaction, Modi-fied-Julia reaction and Julia-kocieński reaction) in total synthesis of natural products in recent years.

Key words: Julia reaction, natural product, total synthesis, olefination, stereo-selectivity

Cite this article

MA Jun-Hai, WANG Fan, WANG Jin-Xin, YOU Qi-Dong. Progress of Julia Olefination in Total Synthesis of Natural Products[J]. Chin. J. Org. Chem., 2010, 30(11): 1615-1623.

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Julia烯烃合成法在天然产物全合成中的应用新进展

Progress of Julia Olefination in Total Synthesis of Natural Products

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