Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 638-646.DOI: 10.6023/cjoc201412030 Previous Articles     Next Articles



李永红, 王君姣, 魏小红, 杨尚东   

  1. 兰州大学功能有机分子国家重点实验室 兰州 730000
  • 收稿日期:2014-12-17 修回日期:2014-12-29 发布日期:2015-01-09
  • 通讯作者: 杨尚东
  • 基金资助:

    国家自然科学基金(No. 21272100)资助项目.

Silver-Catalyzed Tandem Radical Cyclization for the Synthesis of 3,3'-Disubstituted Oxindoles

Li Yonghong, Wang Junjiao, Wei Xiaohong, Yang Shangdong   

  1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000
  • Received:2014-12-17 Revised:2014-12-29 Published:2015-01-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272100).

A new silver-catalyzed oxidative ring opening of cyclopropanols to functionalize alkenes of N-arylacrylamides leading to 3,3'-disubstituted oxindoles has been developed. This reaction is proposed to proceed through oxidative radical ring-opening and C—H functionalization cascade process under the mild reaction conditions with good functional groups tolerance.

Key words: silver-catalyzed, radical tandem cyclization, C—H functionalization, carbonyl-containing 3,3'-disubstituted oxindoles