Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2028-2033.DOI: 10.6023/cjoc201703012 Previous Articles     Next Articles



周盼盼a, 管明玉a, 张静宇b,c, 徐凡a, 赵应声a   

  1. a 苏州大学材料化学化工学部 苏州 215123;
    b 苏州大学物理与光电学部 能源与材料创新研究院 苏州 215123;
    c 江苏省先进碳材料与可穿戴能源技术重点实验室 苏州 215123
  • 收稿日期:2017-03-06 修回日期:2017-04-08 发布日期:2017-04-21
  • 通讯作者: 赵应声
  • 基金资助:


Facile Synthesis of Benzoxazinone Derivatives via Palladium Catalyzed Intramolecular Amination

Zhou Panpana, Guan Mingyua, Zhang Jingyub,c, Xu Fana, Zhao Yingshenga   

  1. a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123;
    b Soochow Institute for Energy and Materials Innovation, College of Physics, Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123;
    c Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Suzhou 215123
  • Received:2017-03-06 Revised:2017-04-08 Published:2017-04-21
  • Contact: 10.6023/cjoc201703012
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21572149) and the Young National Natural Science Foundation of China (Nos. 21402133, 21403148).

Benzoxazinone and its derivatives are well-known as a broad-spectrum of physiological activities compounds. Herein we report a novel approach for the synthesis of benzoxazine derivatives via a N,O-bindentate directing assisted Pd-catalyzed intramolecular amination reactions. Various benzoxazinone derivatives are obtained in moderate to good yields. The directing group can be removed under mild condition, highlighting potential synthetic utility of this method.

Key words: C—H functionalization, palladium catalysis, phenoxyacetic acid, intramolecular amination