Recent Advances in Copper-Catalyzed Asymmetric Conjugate Addition of Grignard Reagents

doi:10.6023/cjoc201501015

Abstract

Copper-catalyzed asymmetric 1,4-, 1,6- and 1,2-conjugate addition of Grignard reagents is an important method to build up a carbon chiral center, which exists in the key intermediates of many natural products and chiral drugs. In this paper, the copper-catalyzed asymmetric 1,4-, 1,6- and 1,2-conjugate addition of Grignard reagents to α,β-unsaturated compounds is summarized systematically, and such acceptors as α,β-unsaturated ketones, esters, lactones, aldehydes, thioesters as well as sulfones are involved. In addition, the mechanism of asymmetric 1,4-conjugate addition is also introduced.

Key words: copper-catalyzed, Grignard reagent, asymmetric conjugate addition, mechanism

Cite this article

Tang Fengxiang, Ye Jiuyong. Recent Advances in Copper-Catalyzed Asymmetric Conjugate Addition of Grignard Reagents[J]. Chin. J. Org. Chem., 2015, 35(7): 1414-1427.

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