Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (8): 2119-2130.DOI: 10.6023/cjoc201904060 Previous Articles     Next Articles

Special Issue: 陈茹玉先生诞辰100周年

Reviews

金属化亚甲胺叶立德在手性非天然α-氨基酸合成中的应用研究进展

卫亮a, 肖露a, 胡远征a, 汪昨非a, 陶海燕a, 王春江a,b   

  1. a 武汉大学化学与分子科学学院 有机硅化合物及材料教育部工程研究中心 武汉 430072;
    b 南开大学 元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2019-04-24 修回日期:2019-05-25 出版日期:2019-08-25 发布日期:2019-06-03
  • 通讯作者: 王春江 E-mail:cjwang@whu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21525207,21772147)和中国博士后科研基金(No.2017M620331)资助项目.

Recent Advances in Metallated Azomethine Ylides for the Synthesis of Chiral Unnatural α-Amino Acids

Wei Lianga, Xiao Lua, Hu Yuanzhenga, Wang Zuofeia, Tao Haiyana, Wang Chunjianga,b   

  1. a Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072;
    b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071
  • Received:2019-04-24 Revised:2019-05-25 Online:2019-08-25 Published:2019-06-03
  • Contact: 10.6023/cjoc201904060 E-mail:cjwang@whu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21525207, 21772147) and the China Postdoctoral Science Foundation (No. 2017M620331).

The development of efficient methods for the preparation of unnatural amino acids has long been an important goal since their widely application in synthetic and medicinal chemistry. The asymmetric α-functionalization of nucleophilic metalated azomethine ylides, which could be in situ-generated from readily-available aldimine esters, has been recogonized as a powerful strategy to synthesize unnatural amino acids. Over the past 20 years, tranistion metal-catalyzed asymmetric construction of unnatural amino acids using azomethine ylides have been extensively studied. In this review, the progress on metallated azomethine ylides invovled aymmetric transformation for the synthesis of unnatural amino acids is summarized according to eletrophilic reagents.

Key words: azomethine ylide, asymmetric catalysis, unnatural α-amino acid