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化学学报
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化学学报 ›› 2000, Vol. 58 ›› Issue (6): 662-665. 上一篇    下一篇

研究论文

锌(Ⅱ)-12-正戊基-1,4,7,10-四氮杂环十三烷-11,13-二 酮-α-氨基酸三元配合 物的稳定性

张向东;刘岩;孙锦玉;刘祁涛   

  1. 辽宁大学化学系.沈阳(110036)
  • 发布日期:2000-06-15

Study on the stability of Zn(Ⅱ)-12-pentyl-1,4,7,10 - tetraazacyclotridecane-11,13-dione-α-amino acids ternary complexes

Zhang Xiangdong;Liu Yan;Sun Jinyu;Liu Qitao   

  1. Liaoning Univ, Dept Chem.Shenyang(110036)
  • Published:2000-06-15

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合成了一种新的双氧四胺大环配体：12-正戊基-1,4,7,10-四氮杂环十三烷-11,13二酮(L)。采用pH电位法，在(25±0.1)℃，I=0.1mol·dm^-^3NaNO~3条件下，测定了锌(Ⅱ)与L的二元配合物及锌(Ⅱ)与L和六种α-氨基酸(AA=Gly,Ala,Val,Leu,Ile,Phe)形成的三元配合物的稳定常数。结合量子化学计算结果，讨论了在双氧四胺大环配体上引入疏水碳链形成具有双亲结构的配体后，与金属离子的配位能力的变化以及形成Zn(L)(AA)三元配合物稳定性变化规律。

关键词: 锌络合物, 氮杂环化合物, 氨基酸, 稳定性

New dioxotetraamine macrocycle (12-pentyl-1,4,7,10- tetraazacyclotridecane-11,13-dione) was synthesized and characterized by elemental analysis, IR, ^1H NMR and MS. By pH potentiometric titration at (25±0.1)℃, I=0.1 mol·dm^-^3 NaNO~3, the ligand protonation constanits and the formation constants of the binary and ternary complexes with zinc were determined. The effect of pentyl group and stabilities of binary and ternary complexes are discussed with the aid of calculation using PM3 method.

Key words: ZINC COMPLEX, NITROGEN HETEROCYCLICS, AMINO ACID, STABILITY

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