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化学学报
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化学学报 ›› 2003, Vol. 61 ›› Issue (12): 1991-1996. 上一篇    下一篇

研究论文

黑鳗藤中C_(21)甾体苷的分离和结构测定

张如松;叶益萍;李晓誉;张晓颖   

  1. 浙江中医学院药学系;浙江省医学科学院药物研究所
  • 发布日期:2003-12-15

Steroidal Glycosides from the Stems of Stephanotis mucronata (Blanco) Merr. (Asclepiadaceae)

Zhang Rusong;Ye Yiping;Li Xiaoyu;Zhang Xiaoying   

  1. Department of Pharmacy, Zhejiang College of Traditional Chinese Medicine;Institute of Materia Medica, Zhejiang Academy of Medical Sciences
  • Published:2003-12-15

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455

被引次数

19

从萝藦科植物黑鳗藤[Stephanotis mucronta (Blanco) Merr.]的藤茎中分离 到三个C_(21)甾体去氧糖苷（1） - （3）。通过化学降解和波谱技术，确定它们 的化学结构依次为：12-O-惕各酰基-20-O-乙酰基肉珊瑚苷元3-O-β-黄夹吡喃糖基 -（1→4）-β-磁麻吡喃糖基-（1→4）-β-磁麻吡喃糖苷（1），5，6-双氢-12-O- 乙酰基-20-O-惕各酰基肉珊瑚苷元3-O-β-黄夹吡喃糖基-（1→4）-β-磁麻吡喃糖 基-（1→4）-β-磁麻吡喃糖基（2）；12-O-乙酰基-20-O（N-甲基）邻氨基苯甲酰 基肉珊瑚甘元3-O-β-黄夹吡喃糖基-（1→4）-β-磁麻吡喃糖基-（1→4）-β-磁 麻吡喃糖甘（3）。其中1和2为新化合物，分别命名为mucronatoside A， mucrontoside B。3为已知化合物stephanoside E，系首次从该植物中分离得到。

关键词: 黑鳗藤, 甾族化合物, 吡喃糖, 糖苷, 分离, 结构

Two new polyoxypregnane glycosides, mucronatoside A (l) and mucronatoside B (2), together with one known stephanoside E (3) were obtained from the stems of Stephaiwtis mucronata (Blanco) Merr. (Asclepiadaceae). Their structures were elucidated as 12-tigloxyl-20-O- acetoxyl sarcostin 3-0-β-thevetopyranosyl-( 1→4 )-β-cymaropyranosyl- ( 1→4 )-β-cymaropyranoside (1); 5,6-dihydro-12-0-acetoxy-2O-O- tigloxyl sarcostin 3-0-β-thevetopyranosyl-(1→4) -β-cymaropyranosyl- (1→4)-β-cymaropyranoside (2); 12- 0-acetoxy-2O- O- ( A'-methyl) anthraniloyl sarcostin 3-0-β-thevetopyranosyl-( 1 → 4 )-β- cymaropyranosyl-( 1→4 )-β-cymaropyranoside ( 3 ), respectively, on the basis of spectroscopic and chemical means.

Key words: Stephanotis mucronata, STEROIDS, PYRANOSE, GLYCOSIDE, ISOLATION, STRUCTURE

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