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化学学报
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化学学报 ›› 2006, Vol. 64 ›› Issue (4): 338-342. 上一篇    下一篇

研究论文

手性环胍衍生物的合成

盛欣，宋伟，陆国元*，王震生   

  1. (南京大学化学系 配位化学国家重点实验室 南京 210093)
  • 投稿日期:2005-06-24 修回日期:2005-10-26 发布日期:2006-02-28
  • 通讯作者: 陆国元

Synthesis of Optically Active Chiral Cyclic Guanidine Derivative

SHENG Xin, SONG Wei, LU Guo-Yuan*, WANG Zheng-Sheng   

  1. (Department of Chemistry, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093)
  • Received:2005-06-24 Revised:2005-10-26 Published:2006-02-28
  • Contact: LU Guo-Yuan

PDF

1094

被引次数

4

以L-天冬酰胺为原料经十步反应合成了光学纯的手性双环胍, 总收率为2.2%. 这一合成方法的优点是避免使用剧毒的硫光气和气味难闻的有机硫化物

关键词: 胍, 双环胍, 手性, 合成

The optically active chiral bicyclic guanidinium chloride, 4S,8S-bis(hydroxymethyl)-1,5,7-tri- azabicyclo[4.4.0]dec-5-ene hydrochloride was synthesized in ten steps from L-asparagine with a total yield of 2.2%. This pathway aviod usage of virulent thiophosgene and horrible smell organic sulfid.

Key words: guanidine, bicyclic guanidine, chirality, synthesis