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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (12): 1297-1302. 上一篇    下一篇

研究论文

两种钒配合物的合成、表征及与Ct-DNA作用研究

周荫庄* 冯静楠 岳 蕾 屠淑洁 朱惠菊

  

  1. (首都师范大学化学系 北京 100048)

  • 投稿日期:2008-07-16 修回日期:2008-12-05 发布日期:2009-06-28
  • 通讯作者: 周荫庄

Synthesis, Characterization and Ct-DNA Interaction Study of Two Vanadium Complexes

Zhou, Yinzhuang* Feng, Jingnan Yue, Lei Tu, Shujie Zhu, Huiju   

  1. (Department of Chemistry, Capital Normal University, Beijing 100048)
  • Received:2008-07-16 Revised:2008-12-05 Published:2009-06-28
  • Contact: Zhou, Yinzhuang

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被引次数

12 | 4

合成了两种钒-邻香草醛衍生物配合物[VO2(C10H11O3N)](HOCH2CH2NH3) (1)和VO(C8H8O3N)2 (2); 用FT-IR和X-ray单晶衍射对它们的晶体结构进行了表征; 用紫外吸收光谱法、荧光光谱法、循环伏安法、粘度法等分析了两种配合物与小牛胸腺DNA (Ct-DNA)的作用; 结果表明配合物1以非插入方式与Ct-DNA作用, 配合物2则以插入方式与Ct-DNA作用.

关键词: 钒, 邻香草醛, 配合物, 嵌插作用, 小牛胸腺DNA

Two vanadium complexes with o-vanillin derivatives, [VO2(C10H11NO3)](HOCH2CH2NH3) (1) and VO(C8H8NO3)2 (2), were synthesized and characterized by FT-IR and single crystal X-ray diffraction analysis. The interaction of the two complexes with calf thymus-DNA (Ct-DNA) has been investigated by UV-Vis absorption spectroscopy, fluorescence spectroscopy, cyclic voltammetry and viscosity measurements. The results indicated that the complex 1 interacted with Ct-DNA in a non-intercalative mode, while complex 2 might be bonded to Ct-DNA through an intercalative mode.

Key words: vanadium, o-vanillin, complex, intercalation interaction, calf thymus DNA