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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (16): 1843-1850. 上一篇    下一篇

研究论文

稀土、钼酸、糠醛缩水杨酰肼三元配合物的合成、 表征及生物活性的研究

夏庆春a 沈智慧a 何其庄*,a 许东芳a 彭子飞a 邵超英b

  

  1. (a上海师范大学生命与环境科学学院 上海 200234)
    (b东华大学化学化工与生物工程学院 上海 201620)

  • 投稿日期:2008-12-24 修回日期:2009-02-17 发布日期:2009-08-28
  • 通讯作者: 何其庄

Synthesis, Characterization and Biological Activity of Rare Earth Complexes with Fural Salicylhydrazone and Molybdic Acid

Xia, Qingchun a Shen, Zhihui a He, Qizhuang *,a Xu, Dongfang a
Peng, Zifei a Shao, Chaoying b
  

  1. (a Department of Chemistry, Shanghai Normal University, Shanghai 200234)
    (b College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620)
  • Received:2008-12-24 Revised:2009-02-17 Published:2009-08-28

PDF

1580

被引次数

55

通过回流冷凝法和低温固相法制备了8种稀土、钼酸、糠醛缩水杨酰肼三元配合物, 并通过元素分析, 摩尔电导, IR, UV-vis, TG-DTA, TC-ICP, XRD, XPS对其结构和化学组成进行表征, 确定其化学组成为Re(HL)MoO4Cl•6H2O (HL: 糠醛缩水杨酰肼), 通过抑菌实验表明所制备的三元化合物对大肠杆菌和金黄色葡萄球菌具有中等抑制作用, 属于广谱抗菌剂; 通过MTT比色法对配合物使癌细胞凋亡能力做了初步研究, 结果表明, 三元配合物的IC50在10～100 ng/mL之间, 对癌细胞具有较强的抑制杀伤作用, 具有潜在的药物应用价值.

关键词: 配合物, 抑菌, 抗肿瘤

Using a reflux condensation method and a low-temperature solid phase method, eight kinds of new ternary complexes were synthesized with rare earth chloride, molybdenum acid and fural salicylhydrazone. Their compositions were characterized by elemental analysis, molar conductance, FT-IR, UV-vis, TG-DTA, TC-ICP, XRD and XPS, and confirmed to be Re(HL)MoO4Cl•6H2O (HL: fural salicylhydrazone). The antibacterial activity testing shows that all the complexes exhibit antibacterial ability against Escherichia coli and Staphylococcus aureus. The antimicrobial spectrum of the complexes is broad. MTT was used to study the anticancer ability of the complexes, which indicates that the cancer cells were killed by the complexes. All the complexes have potential drug application.

Key words: complex, antibacterial, anti-tumour