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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (23): 2449-2456. 上一篇    下一篇

研究论文

MePEG-b-PCL-b-PDMAEMA的可控合成及性能研究

朱亚明，张琰*，刘子路，郎美东*   

  1. (华东理工大学材料科学与工程学院 超细材料制备与应用教育部重点实验室 上海先进聚合物材料重点实验室
    上海 200237)
  • 投稿日期:2010-07-18 修回日期:2010-08-18 发布日期:2010-08-18
  • 通讯作者: 郎美东 E-mail:mdlang@ecust.edu.cn;mdlang@fudan.edu.cn

Controlled Synthesis and Properties of Triblock MePEG-b-PCL-b-PDMAEMA

ZHU Ya-Ming, ZHANG Yan, LIU Zi-Lu, LANG Mei-Dong   

  1. (Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237)
  • Received:2010-07-18 Revised:2010-08-18 Published:2010-08-18
  • Contact: Lang Ｍｅｉｄｏｎｇ E-mail:mdlang@ecust.edu.cn;mdlang@fudan.edu.cn

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采用可控开环聚合(ROP)和原子转移自由基聚合(ATRP)相结合的方法制备出一系列单甲氧基聚乙二醇-b-聚(ε-己内酯)-b-聚甲基丙烯酸-N,N-二甲氨基乙酯(MePEG-b-PCL-b-PDMAEMA). 采用核磁(1H NMR)和凝胶渗透色谱(GPC)研究了聚合物的结构并对聚合物的分子量大小和分布进行了表征. 聚合物的热稳定性能、结晶性能和亲水性能分别由热重分析仪(TGA)、X-衍射仪(XRD)和静态水滴接触角测定. 分别采用荧光光谱法和1H NMR(以D2O为溶剂)方法研究了聚合物纳米粒子的形成. 激光光散射(DLS)和透射电镜(TEM)研究结果表明聚合物纳米粒子具有球形结构, 粒子大小在40～70 nm之间并且对外界环境具有pH敏感性能. MePEG-b-PCL-b-PDMAEMA纳米粒子在同时包裹带有正电荷药物以及疏水性药物方面具有潜在的应用前景.

关键词: 原子转移自由基聚合(ATRP), 自组装, 两亲性, pH响应

A series of well-controlled triblock methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b- poly[2-(dimethylamino) ethyl methacrylate] (MePEG-b-PCL-b-PDMAEMA) was obtained by ring open polymerization (ROP) and atom transfer radical polymerization (ATRP) methods. Their structures and composition were confirmed by 1H nuclear magnetic resonance (1H NMR), and the molecule weight and molecular weight distribution of the copolymers were obtained by 1H NMR and gel permeation chromatography (GPC). The thermal stability, crystallization property and hydrophiphilicity were evidenced by thermogravimetric analysis, X-ray diffraction (XRD) and static water contact angle measurements. The formation of the nanoparticles was studied by 1H NMR in D2O and fluorescence probe method. The transmission electron microscopy (TEM) displayed that the morphologies of the nanoparticles were spherical and the size was on nano scale. Dynamic light scattering (DLS) indicated that the nanoparticles were in the range of 40～70 nm, and in different pH solution, the nanoparticles showed good pH-sensitivity. Due to the hydrophobic core and the cationic hydrophilic shell, the nanoparticles has great potential application for the codelivery of hydrophobic drugs and negative drugs.

Key words: atom transfer radical polymerization (ATRP), self-assembly, amphiphilic, pH-responsive