关键词: 咪唑 P, 反应机理, 重水, 浓度, 烷基化, 活化能, 反应速度常数, Ｎ-烷基, 水相, 相移转催化

The effect of heavy water on N-alkylation of imidazole and its derivatives under phase transfer catalytic condition was discussed. It is demonstrated that heavy water shows significant solvent isotope effect, associated with the increase of basicity of imidazole and pyrazole. The reaction rate of N-n-butylation in PTC in H2O and D2O were determine

Key words: IMIDAZOLE P, REACTION MECHANISM, HEAVY WATER, CONCENTRATION, ALKYLATION, ACTIVATION ENERGY, REACTION RATE CONSTANT, N-ALKYL GROUP, WATER PHASE, PHASE TRANSFER CATALYSIS