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化学学报
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化学学报 ›› 2006, Vol. 64 ›› Issue (21): 2169-2172. 上一篇    下一篇

研究论文

配合物[Co(qina)2(H2O)2]•2DMSO的晶体结构及其与DNA作用研究

高恩君*,1,2, 程卯生2, 王克华1, 孙亚光1   

  1. (1沈阳化工学院配位化学研究室 沈阳 110142)
    (2沈阳药科大学制药工程学院 沈阳 110015)
  • 投稿日期:2006-01-05 修回日期:2006-05-11 发布日期:2006-11-14
  • 通讯作者: 高恩君

Study on Crystal Structure of Complex [Co(qina)2(H2O)2]•2DMSO and Interaction with DNA

GAO En-Jun*,1,2; CHENG Mao-Sheng2; WANG Ke-Hua1; SUN Ya-Guang1   

  1. (1 Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142)
    (2 College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110015)
  • Received:2006-01-05 Revised:2006-05-11 Published:2006-11-14
  • Contact: GAO En-Jun

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合成了配合物[Co(qina)2(H2O)2]•2DMSO单晶(qina为喹哪啶酸). 配合物属于单斜晶系, P2(1)/n空间群, 其分子结构为规则的八面体构型, qina以氮原子和羧酸根氧原子与Co2＋离子配位, 两个水分子为轴向配位. 配合物之间富有配位水分子分别与DMSO的氧原子、qina中未与Co(II)配位的氧之间氢键作用. 配合物与鱼精DNA作用的紫外光谱和荧光光谱表明, 两者之间有一定的相互作用, 并可能以局部插入方式为主.

关键词: 钴(II), 喹哪啶酸, 配合物, 氢键

The complex [Co(qina)2(H2O)2]•2DMSO (qina＝quinaldic acid) was synthesized. The title complex belongs to monoclinic system with space group of P2(1)/n, and renders a regular octahedral geometry. Qina coordinates to Co2＋ with nitrogen atoms and oxygen atoms of carboxylic group; oxygen atoms of coordinated water occupy the axial positions. There are hydrogen bonds interaction among coordinated water, oxygen atoms of DMSO, uncoordinated oxygen atoms of qina. UV-Vis spectra and fluorescence spectra of complex interacted with DNA show there are interaction between title complex and sperm DNA, and insertion is main binding mode.

Key words: cobalt(II), quinaldic acid, complex, hydrogen bond