化学学报 ›› 2001, Vol. 59 ›› Issue (10): 1763-1768. 上一篇    下一篇

研究论文

烯酮缩胺与芳基异硫氰酸酯的反应: 合成异噻唑化合物 的一个途径

赵梅欣;王梅祥;黄志镗   

  1. 中国科学院化学研究所分子科学中心
  • 发布日期:2001-10-15

Reaction of ketene aminals with aryl isothiocyanates: A simple route to isothiazole compounds

Zhao Meixin;Wang Meixiang;Huang Zhitang   

  • Published:2001-10-15

具有不同取代基的五状和非环状的烯酮缩胺与芳基异硫氰酸酯在两酮中回流,可高产率地获得α-碳加成产物,该产物在溴存在下可氧化关环生成异噻唑类化合物。

关键词: 烯酮, 缩胺, 异硫氰酸酯, 恶唑, 氧化, 闭环反应

Cyclic and acyclic ketene aminals with different electron withdrawing groups reacted with aryl isothiocyanates to give he corresponding α-carbon adducts in high yield which underwent oxidative cyclization with bromine to afford isothiazole compounds in moderate yield.

Key words: KETENE, ISOTHIOCYANATE, OXAZOLE, OXIDATION, RING CLOSURE REACTION

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