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化学学报
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化学学报 ›› 1991, Vol. 49 ›› Issue (4): 412-416. 上一篇    

研究论文

五脂酮A, B和Butyryl Binankadsurin A的分离与结构

刘嘉森;周洪星   

  1. 中国科学院上海药物研究所.上海(200031)
  • 发布日期:1991-04-15

Isolation and structures of Schisanlignone A, B and butyryl binankadsurin A

Liu Jiasen;Zhou Hongxing   

  1. Shanghai Inst Mat Med., CAS.Shanghai(200031)
  • Published:1991-04-15

PDF

455

被引次数

14

从采自广西柳州地区融水县的一种南五味子(Kadsurasp.)种子中分得三个已知化合物---binankadsurinA(1),acetylbinankadsurinA(2),angeloylbinankadsurinA(3)及三个新化合物---五脂酮(schisanlignone)A(4),B(5),butyrylbinankadsurinA(6)。它们的结构由光谱分析和化学转化而阐明。1系首次从自然界分得。在抗癌药理筛选中,4与5在体外都对白血病P-388细胞有抑制作用。其IC~5~0分别为10和40μg/mL。

关键词: 分离, 五脂酮, 五味子科, 结构, 化学转化, 光谱分析, 白血病, 抗癌药

Three new lignan compounds named Schisanlignone A(4), B(5) and butyryl binankadsurin A(6) along with three known lignans, binankadsurin A(1), acetyl binankadsurin A(2) and angeloyl binankadsurin A(3), were isolated from the seeds of a kadsura sp. collected in Rongshui county of Guangxi, China. Their structure elucidation including absolute configurations relies on chemical conversions of 4 into (+)-deoxyschizandrin (4a), of 5 into 4, and of 6 into 1 besides the routine spectral analysis. 4 and 5 show a significant activity against Leukaema P-388 cell (IC~5~0 10 and 40μ g/mL respectively) in vitro.

Key words: SEPARATION, STRUCTURE, SPECTROGRAPHIC ANALYSIS, LEUKEMIA, ANTICARCINOGEN

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