化学学报 ›› 2012, Vol. 70 ›› Issue (02): 195-199.DOI: 10.6023/A1104254 上一篇    下一篇

研究论文

金属螺旋三角形穴状化合物的组装及其对氨基葡萄糖的识别研究

吴红梅, 郭宇   

  1. 辽宁工业大学化学与环境工程学院 锦州 121001
  • 投稿日期:2011-04-25 修回日期:2011-09-20 发布日期:2012-02-25
  • 通讯作者: 吴红梅 E-mail:wuhongmei0331@126.com
  • 基金资助:

    国家自然科学基金(No.20801008);辽宁省教育厅科学研究一般项目(No.L2011105)和辽宁工业大学教师科研启动基金(No.X201116)资助项目.

Assembly of Metallohelical Triangle Cryptate for Recognition of Glucosamine

Wu Hongmei, Guo Yu   

  1. School of Chemical and Environmental Engineering, Liaoning University of Technology, Jinzhou 121001
  • Received:2011-04-25 Revised:2011-09-20 Published:2012-02-25
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.20801008);Science & Research Project of Liaoning Province Eduction Deparatment (No.L2011105);Teacher Start-up Fund of Science & Research Foundation of Liaoning University of Technology (No.X201116).

利用含有丹磺酰胺荧光团和氢键作用位点的双三齿(N2O)有机配体H2L1[(N-(3,5-双(2-(2-吡啶亚甲基)甲酰肼基))苯基)-5-(二甲基氨基)萘-1-磺酰胺]与Zn2+构筑金属螺旋三角形穴状化合物MC-1. 通过荧光光谱、紫外光谱和ESI-MS测试及1H NMR 测定, 研究其对氨基葡萄糖和葡萄糖的识别与传感. 结果表明, MC-1 对氨基葡萄糖具有良好的荧光和紫外双重响应, 而对葡萄糖却没有任何响应, 且MC-1 能够1:1 包合氨基葡萄糖, 平衡常数lgKass=7.23±0.03.

关键词: 穴状化合物, 氨基葡萄糖, 丹磺酰胺, 识别

Metallohelical triangle cryptate MC-1 was assembled by Zn2+ and two tridentate (N2O) ligand H2L1 [N-(3,5-bis((E)-2-(pyridin-2-ylmethylene)hydrazinecarbonyl)phenyl)-5-(dimethylamino)napthalene-1-sulfonamide] with dansyl sulfonamide group and hydrogen bond site. UV-vis and fluorescence spectra, ESI-MS and 1H NMR of MC-1 were measured for recognition of glucosamine and glucose. It was found that MC-1 exhibited good response of UV-vis and fluorescene toward glucosamine, but no response for glucose. Moreover, 1:1 stoichiometric host-guest complexation of MC-1 for glucosamine was confirmed by the titration profile and electrospray ionization mass spectrometry (ESI-MS) spectrum, with an association constant (lgKass) being calculated as 7.23±0.03.

Key words: cryptate, glucosamine, dansyl sulfonamide, recognition