FeCl2-Catalyzed Oxidative Amidation of Aldehydes with Primary and Secondary Amines

doi:10.6023/A15040287

Acta Chim. Sinica ›› 2015, Vol. 73 ›› Issue (12): 1311-1314.DOI: 10.6023/A15040287 Previous Articles Next Articles

Special Issue: 碳氢键官能团化

Communication

氯化亚铁催化的醛与伯胺和仲胺的氧化酰胺化反应

李远明, 贾凡, 马丽娜, 李志平

中国人民大学化学系北京 100872

投稿日期:2015-04-27 发布日期:2015-06-15
通讯作者: 李志平 E-mail:zhipingli@ruc.edu.cn
基金资助:
项目受中国人民大学科学研究基金(中央高校基本科研业务费专项资金资助)项目成果(No.10XNL017)资助.

FeCl₂-Catalyzed Oxidative Amidation of Aldehydes with Primary and Secondary Amines

Li Yuanming, Jia Fan, Ma Lina, Li Zhiping

Department of Chemistry, Renmin University of China, Beijing 100872

Received:2015-04-27 Published:2015-06-15
Supported by:
Project supported by the Fundamental Research Funds for the Central Universities and the Research Funds of Renmin University of China(No. 10XNL017).

1. FeCl₂-Catalyzed Oxidative Amidation of Aldehydes with Primary and Secondary Amines.PDF(266KB)

Abstract

The amidation reaction is an important process in both academia and industry for the synthesis of natural products, functional polymers, and pharmaceuticals. The development of new amidation methods for constructing such important class of organic compounds is still attracting considerable interests. We herein reported a general oxidative amidation of aldehydes with a variety of free primary or secondary amines using inexpensive iron(II) chloride as catalyst and tert-butyl hydroperoxide(TBHP) as oxidant. The present amidation reactions afford the corresponding secondary and tertiary amides in moderate to excellent yields. In addition, the amidations of benzimidazole and pyrazole were also achieved by the developed method.

Key words: iron catalysis, oxidative, amidation, aldehyde, amine

Cite this article

Li Yuanming, Jia Fan, Ma Lina, Li Zhiping. FeCl₂-Catalyzed Oxidative Amidation of Aldehydes with Primary and Secondary Amines[J]. Acta Chim. Sinica, 2015, 73(12): 1311-1314.

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氯化亚铁催化的醛与伯胺和仲胺的氧化酰胺化反应

FeCl₂-Catalyzed Oxidative Amidation of Aldehydes with Primary and Secondary Amines

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