Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (8): 967-978.DOI: 10.6023/A23040172 Previous Articles     Next Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑



魏文杰, 陈文龙, 戴晓彬, 燕立唐()   

  1. 清华大学化学工程系 北京 100084
  • 投稿日期:2023-04-27 发布日期:2023-09-14
  • 作者简介:

    魏文杰, 清华大学化学工程系在读博士研究生. 2022年本科毕业于清华大学. 目前主要从事大分子体系中活性粒子的扩散动力学计算机模拟研究.

    陈文龙, 清华大学化学工程系在读博士研究生. 2022年本科毕业于清华大学. 主要从事大分子网络中扩散动力学的计算机模拟研究.

    戴晓彬, 清华大学化学工程系在读博士研究生. 2014年本科毕业于清华大学. 主要从事大分子的计算机理论计算与模拟研究, 包括聚合物纳米复合体系, 大分子网络体系等.

    燕立唐, 清华大学化工系长聘教授. 主要研究方向为, 结合现代软凝聚态物理与传统高分子物理, 发展新的计算模型和解析理论, 应用于大分子组装、凝胶体系以及生命大分子体系的基础理论研究. 曾获德国洪堡学者基金, 国家基金委优秀青年基金和国家杰出青年科学基金项目资助.

    † 共同第一作者
  • 基金资助:
    项目受国家重点基础研究发展规划(2022YFA1200061); 国家自然科学基金(22025302); 国家自然科学基金(21873053); 化学工程联合国家重点实验室(SKL-ChE-23T01)

Theory of Anomalous Diffusion Dynamics in Biomacromolecular Media

Wenjie Wei, Wenlong Chen, Xiaobin Dai, Li-Tang Yan()   

  1. Department of Chemical Engineering, Tsinghua University, Beijing 100084
  • Received:2023-04-27 Published:2023-09-14
  • Contact: *E-mail:
  • About author:
    Dedicated to the 90th anniversary of Acta Chimica Sinica.
    † These authors contributed equally to this work.
  • Supported by:
    State Key Development Program of Basic Research of China(2022YFA1200061); National Natural Science Foundation of China(22025302); National Natural Science Foundation of China(21873053); State Key Laboratory of Chemical Engineering(SKL-ChE-23T01)

Diffusion behavior in life system involves important life processes such as nutrient uptake and drug delivery. A deeper understanding about diffusive behavior of particles in complex biomacromolecular media will facilitate the understanding of relevant life phenomena as well as the development of novel medical materials. The diffusion behavior in biomacromolecular media is often anomalous and cannot be described simply based on the conventional diffusion constant equation. This is usually attributed to the continuous correlation of diffusion caused by crowded environment and complex interactions in biological medium, which leads to the central limit theorem no longer applicable. The mechanism and physical characteristics of anomalous diffusion were analyzed from three aspects: diffusion coefficient, mean square displacement, and displacement probability distribution function. The recent progress of anomalous diffusion in biomacromolecular media was summarized. The physical model and existing theoretical framework of anomalous diffusion are then outlined. Finally, the future direction of anomalous diffusion dynamics in biomacromolecular media is discussed.

Key words: diffusion, anomalous diffusion, nanoparticle, biomacromolecular media, dynamics heterogeneity