The binding mode and configuration of cisplatin with F-actin were studied on the basis of charge transfer bands in the electronic spectra of cisplatin and cisplatin-F0-actin. The spectra were resolved to individual absorption bands and were compared with the calculated values corresponding to different binding configurations and ligating atoms. The results indicate a square planar configuration with two ammonia nitrogen, one sulfur and one amino nitrogen binding to platinum.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, PLATINUM COMPLEX, CLSPLATINUM, CLSPLATINUM, COORDINATION