Study on the interaction of human serum albumin with  Cu(II) and Fe (III) by fluorescence method

Acta Chimica Sinica ›› 1999, Vol. 57 ›› Issue (2): 161-165. Previous Articles Next Articles

Original Articles

Cu(II), Fe(III)与人血清白蛋白相互作用的荧光光谱研究

梁宏;邢本刚;吴庆轩;罗济文;周永洽;申泮文

广西师范大学化学系.桂林(541004);南开大学化学系.天津(300071)

发布日期:1999-02-15

Study on the interaction of human serum albumin with Cu(II) and Fe (III) by fluorescence method

Liang Hong;Xing Bengang;Wu Qingxuan;Luo Jiwen;Zhou Yongqia;Shen Panwen

Guangxi Normal Univ, Dept Chem.Guilin(541004);Nankai Univ, Dept Chem. Tianjin(300071)

Published:1999-02-15

Abstract

The mechanism of Cu(II) and Fe(III) binding to human serum albumin has been studied through the quenching of the intrinsic fluorescence of HSA. Based on Forster non-radiative energy transfer theory, the distance (1.8nm) between Trp-214 residue of HSA and the first class of binding site was determined. The different interaction of Cu(II), Fe(III) with HSA has also been discussed in this paper.

Key words: COPPER, IRON, SERUM PROTEINS, ALBUMINE, INTERACTIONS

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Cite this article

Liang Hong;Xing Bengang;Wu Qingxuan;Luo Jiwen;Zhou Yongqia;Shen Panwen. Study on the interaction of human serum albumin with Cu(II) and Fe (III) by fluorescence method[J]. Acta Chimica Sinica, 1999, 57(2): 161-165.

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Cu(II), Fe(III)与人血清白蛋白相互作用的荧光光谱研究

Study on the interaction of human serum albumin with Cu(II) and Fe (III) by fluorescence method

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