Synthesis, Anti-HIV-1 Activity Study of Keggin Type Heteropoly Blues Containing Glycine

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (2): 170-175. Previous Articles Next Articles

含有甘氨酸的Keggin型杂多蓝的合成和抗艾滋病毒(HIV-1)活性研究

刘术侠¹, 王恩波¹, 翟宏菊¹, 韩正波¹, 曾毅², 李泽琳²

1. 东北师范大学化学学院多酸研究所, 长春, 130024;
2. 中国预防医学科学院, 北京, 100050

投稿日期:2003-03-13 修回日期:2003-08-25 发布日期:2014-01-26
通讯作者: 刘术侠,E-mail:liusx@nenu.edu.cn E-mail:liusx@nenu.edu.cn
基金资助:
国家自然科学基金(No.20071008)资助项目.

Synthesis, Anti-HIV-1 Activity Study of Keggin Type Heteropoly Blues Containing Glycine

LIU Shu-Xia¹, WANG En-Bo¹, ZHAI Hong-Ju¹, HAN Zheng-Bo¹, ZENG Yi², LI Ze-Lin²

1. Institute of Polyoxometalate Chemistry, Department of Chemistry, Northeast Normal University, Changchun 130024;
2. Chinese Academy of Preventive Medicine Science, Beijing 100050

Received:2003-03-13 Revised:2003-08-25 Published:2014-01-26

Abstract

By means of controlled potential electrolysis, eight Keggin type heteropoly blue containing glycine coordination compounds have been synthesized. Their structures were characterized by IR, UV-vis, ¹H NMR, 183 W NMR and XPS. This kind of compounds showed a good anti-base decomposition ability. The anti-HIV activities and toxicities of these compounds have been determined in human T lymph cells MT-4. It has been found that the anti-HIV activity tends to be stronger with the increase of the number of reducing electrons. Of them the four-electron heteropoly blue of glycine-containing dodecatungstogermanate (HPBG 110) has a high therapeusis index (TI). The results of the elementary test showed that the compounds played a role in anti-HIV activity by inhibiting HIV-1 absorption to the target cells surface in the early stage of virus infection.

Key words: glycine, Keggin type heteropoly blue, synthesis, anti-HIV21 activity, mechanism

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LIU Shu-Xia, WANG En-Bo, ZHAI Hong-Ju, HAN Zheng-Bo, ZENG Yi, LI Ze-Lin. Synthesis, Anti-HIV-1 Activity Study of Keggin Type Heteropoly Blues Containing Glycine[J]. Acta Chimica Sinica, 2004, 62(2): 170-175.

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含有甘氨酸的Keggin型杂多蓝的合成和抗艾滋病毒(HIV-1)活性研究

Synthesis, Anti-HIV-1 Activity Study of Keggin Type Heteropoly Blues Containing Glycine

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