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Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (21): 2169-2172. Previous Articles     Next Articles

Original Articles

配合物[Co(qina)2(H2O)2]•2DMSO的晶体结构及其与DNA作用研究

高恩君*,1,2, 程卯生2, 王克华1, 孙亚光1   

  1. (1沈阳化工学院配位化学研究室 沈阳 110142)
    (2沈阳药科大学制药工程学院 沈阳 110015)
  • 投稿日期:2006-01-05 修回日期:2006-05-11 发布日期:2006-11-14
  • 通讯作者: 高恩君

Study on Crystal Structure of Complex [Co(qina)2(H2O)2]•2DMSO and Interaction with DNA

GAO En-Jun*,1,2; CHENG Mao-Sheng2; WANG Ke-Hua1; SUN Ya-Guang1   

  1. (1 Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142)
    (2 College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110015)
  • Received:2006-01-05 Revised:2006-05-11 Published:2006-11-14
  • Contact: GAO En-Jun

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The complex [Co(qina)2(H2O)2]•2DMSO (qina＝quinaldic acid) was synthesized. The title complex belongs to monoclinic system with space group of P2(1)/n, and renders a regular octahedral geometry. Qina coordinates to Co2＋ with nitrogen atoms and oxygen atoms of carboxylic group; oxygen atoms of coordinated water occupy the axial positions. There are hydrogen bonds interaction among coordinated water, oxygen atoms of DMSO, uncoordinated oxygen atoms of qina. UV-Vis spectra and fluorescence spectra of complex interacted with DNA show there are interaction between title complex and sperm DNA, and insertion is main binding mode.

Key words: cobalt(II), quinaldic acid, complex, hydrogen bond