Influence of Cucurbit(n＝7,8)uril on the Solubility and Stability of Chlorambucil

Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (12): 1431-1437. Previous Articles Next Articles

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七、八元瓜环对抗癌药物苯丁酸氮芥稳定性和溶解度的影响研究

董南*^,1,2，王秀林²，盘金品²，陶朱^1,2

(¹贵州省大环化学及超分子化学重点实验室贵州大学贵阳 550025)
(²贵州大学化学与化工学院贵阳 550025)

投稿日期:2010-10-13 修回日期:2011-01-05 发布日期:2011-02-24
通讯作者: 董南 E-mail:sci.ldong@gzu.edu.cn
基金资助:
贵州省省长基金资助;贵州省自然科学基金资助项目;贵州大学人才引进项目;国家自然科学基金项目

Influence of Cucurbit(n＝7,8)uril on the Solubility and Stability of Chlorambucil

Dong Nan*^,1,2 Wang Xiulin² Pan Jinpin² Tao Zhu^1,2

(¹Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025)
(²School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025)

Received:2010-10-13 Revised:2011-01-05 Published:2011-02-24

The effects of cucurbit(n＝7,8)uril (Q[7,8]) on the solubility and stability of chlorambucil (CHL) have been investigated. The results from high performance liquid chromatography indicated that in the presence of 2.0×10^－4 mol•L^－1 Q[7], there is a 4-fold increase in the stability of chlorambucil at 37 ℃, pH 2.0, while a greater 15-fold increase in the presence of 8.0×10^－5 mol•L^－1 Q[8] under same conditions. Aqueous solubility of CHL is increased more than 6-fold or 36-fold increase in the presence of 1.0×10^－4 mol•L^－1 Q[8] or 1.0×10^－3 mol•L^－1 Q[7] respectively under conditions where degradation is minimized (3 ℃, pH 2.0). Stability constants of the CHL complex with Q[7,8] were determined kinetically and spectrophotometrically under various experimental conditions assuming 1∶1 inclusion complex formation. ¹H NMR further confirmed that Q[7,8] could form complexes with CHL and the possible interaction models were proposed.

Key words: cucurbit(n＝7,8)uril, chlorambucil, stability, aqueous solubility, interaction

Cite this article

DONG Nan, WANG Xiu-Lin, PAN Jin-Pin, TAO Zhu. Influence of Cucurbit(n＝7,8)uril on the Solubility and Stability of Chlorambucil[J]. Acta Chimica Sinica, 2011, 69(12): 1431-1437.

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七、八元瓜环对抗癌药物苯丁酸氮芥稳定性和溶解度的影响研究

Influence of Cucurbit(n＝7,8)uril on the Solubility and Stability of Chlorambucil

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