Intramolecular reaction and intramolecular catalysis I: An approach to the hydrolysis mechanism of intramolecular general base-catalysis by the benzimidazolyl group of ethyl 2-(2'-benzimidazolyl)acetate and ethyl 3-(2'-benzimidazolyl)propionate

Acta Chimica Sinica ›› 1990, Vol. 48 ›› Issue (5): 506-510. Previous Articles Next Articles

Original Articles

分子内反应与分子内催化I:分子内苯并咪唑基一般碱催化2-(2'-苯并咪唑基)乙酸乙酯及3-(2'-苯并咪唑基)丙酸乙酯水解机理的探讨

夏炽中;夏道宏

山西大学分子科学研究所

发布日期:1990-05-15

Intramolecular reaction and intramolecular catalysis I: An approach to the hydrolysis mechanism of intramolecular general base-catalysis by the benzimidazolyl group of ethyl 2-(2'-benzimidazolyl)acetate and ethyl 3-(2'-benzimidazolyl)propionate

XIA CHIZHONG;XIA DAOHONG

Published:1990-05-15

Abstract

The observed hydrolysis rate constants of the title compounds were determine at different pH values. The experimental results show that in more alkaline solution, the intermol. specific base-catalyzed hydrolysis of these two esters by hydroxide ion predominates, while at pH values close to neutral the intramol. general base-catalyzed hydrolysis of esters by the benzimidazolyl group occurs.

Key words: CATALYSIS, METHYLACETIC ACID P, REACTION MECHANISM, ETHYL ACETATE, ETHYL ESTER, BENZIMIDAZOLE, BASE, HYROLYSIS

CLC Number:

O641

Cite this article

XIA CHIZHONG;XIA DAOHONG. Intramolecular reaction and intramolecular catalysis I: An approach to the hydrolysis mechanism of intramolecular general base-catalysis by the benzimidazolyl group of ethyl 2-(2'-benzimidazolyl)acetate and ethyl 3-(2'-benzimidazolyl)propionate[J]. Acta Chimica Sinica, 1990, 48(5): 506-510.

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分子内反应与分子内催化I:分子内苯并咪唑基一般碱催化2-(2'-苯并咪唑基)乙酸乙酯及3-(2'-苯并咪唑基)丙酸乙酯水解机理的探讨

Intramolecular reaction and intramolecular catalysis I: An approach to the hydrolysis mechanism of intramolecular general base-catalysis by the benzimidazolyl group of ethyl 2-(2'-benzimidazolyl)acetate and ethyl 3-(2'-benzimidazolyl)propionate

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