A method of mild and selective detritylation is reported. The sugar derivatives with a variety of protective groups, were detritylated with 4-MeC6H4SO3H (0.1-0.2 equivalent) in CH2Cl2 at room temperature Acid sensitive groups such as isopropylidene, methoxylmethyl (MOM), methoxyl ethoxyl Me (MEM), tert-butyldimethylsilyl (TBDMS), and glycosidic benzoyl survived. With pentose derivatives containing two trityls at 1-, 5-position, 1-trityloxy can be cleaved selectively at lower reaction temperature and shorter reaction time,. Yields range from 53 to 90%.

Key words: SELECTIVITY, GLUCOSE, FURANOSE, REMOVAL, TRIPHENYLMETHANE, PROTECTIVE GROUP